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In addition to the Longvida® Optimized Curcumin licensing agreement, Proventigen announced it has signed a licensing agreement to use POMELLA®, a natural and patented pomegranate extract in its product line. POMELLA® was also developed by leading medical researchers in an effort to have a reproducible and superior absorbing pomegranate extract.

Proventigen’s proprietary formulations feature ingredients with superior absorption profiles that focus on Brain Health, Breast/Prostate Health, Colon Health and Joint Health.

Both Longvida® Optimized Curcumin and POMELLA® pomegranate extract are used in Proventigen’s Selective Response Modulators™ (SRM) formula, the company’s flagship product.

“A elite team of medical researchers from a prestigious Southern California Medical School, discovered a natural and patented process to enhance Curcumin’s absorption and deliver it to the blood stream and brain at meaningful and therapeutic levels all without the use of piperine, a black pepper extract that can interfere with the metabolism of many drugs,” said Dr. Michael Nelson, Chief Science Officer, Proventigen. “We looked at numerous Curcumin extracts during our search to create Proventigen SRM™, and Longvida® Optimized Curcumin stood heads and tails above the rest.”

Researchers from around the globe have been feverishly trying to develop new methods to allow Curcumin to better absorb in the human body due to the Curcumin’s ability to influence some of the major pathways associated with Alzheimer’s disease, Cancer and Inflammation.

Longvida® Optimized Curcumin has 65 times the absorption of other Curcumin products and was shown in laboratory studies to cross the blood brain barrier. These findings spurred funding for two National Institutes of Health (NIH) studies looking at Alzheimer’s disease and the use of Longvida® Optimized Curcumin. Researchers at a leading Southern California School of Medicine have been working to develop Longvida® Optimized Curcumin with high absorption for more than two years before they were able to demonstrate their positive findings

POMELLA® is a natural and patented pomegranate extract that has superior absorption levels and antioxidant capacity compared to other pomegranate extract or pills on the market today. POMELLA® has been shown to increase antioxidant support in humans by over 30% in 30 minutes after ingestion. Unlike other pomegranate products, POMELLA® contains high levels of polyphenol antioxidants that will not breakdown due to its patented natural composition.

“Pomegranates polyphenols have a profound influence on key pathways that we are interested in such as aromatase, quinone reductase and CYP1B1  — all which we target in Proventigen SRM™,” added Nelson. “POMELLA® is the ultimate phytochemical and has been clinically researched to show that its punicalagins are preserved, enter the body intact, and are able to release ellagic acid into the bloodstream. No other pomegranate pill or extract on the market even comes close to matching POMELLA®.”

Proventigen Selective Response Modulators™ (SRM) formula contains a proprietary blend of patent-pending Longvida® Optimized Curcumin, patented POMELLA® pomegranate extract, N-aceytlcysteine (NAC) and B-vitamins including Folinic Acid, Methylcobalamin and B6.  This unique blend of pharmaceutical grade compounds support pathways to optimal health!

To learn more about Proventigen and Proventigen SRM™, visit www.proventigen.com or call 1-888-537-2112.

Every 13 minutes, someone dies of breast cancer

Breast health begins with supporting proper estrogen metabolism in breast tissue. Because there is a direct link to imbalanced estrogen metabolism and breast health it is important to support these pathways.

Imbalances in estrogen metabolism can mutate breast tissue DNA that can set the stage for improper cellular replication. Supporting estrogen metabolism is critical to minimize DNA damage and beast health.

Studies have shown that DNA damage occurs in breast tissue as a result of imbalances estrogen metabolism. Because women are exposed to decades of estrogen proper support is key for breast health.  Proventigen Selective Response Modulators™ (SRM) formula supports proper estrogen metabolism by addressing the key pathways involved in breast health.

Key Pathways Involved in Breast Health are:

• Aromatase
• Quinone Reductase
• Glutathione
• CYP1B1
• Catechol-O-methyltransferase (COMT)

Proventigen’s SRM™ blend is a comprehensive approach that naturally supports proper estrogen metabolism and balance in the body.  Letting Nature Nurture.

Curcumin, CYP1B1 and Breast Health

Curcumin Reduces the Biotransforming Enzyme CYP1B1

Curcumin is a superstar when it comes to the many hats it wears. Curcumin supports breast health by reducing the biotransforming enzyme CYP1B1.

CYP1B1 is responsible for making the highly reactive estrogen intermediate that can mutate breast tissue DNA. Supporting CYP1B1 may reduce the DNA adduct formations associated with unbalanced estrogen metabolism.

Curcumin is also a potent antioxidant. Elevated oxidative stress has been an underlying theme for many chronic health condition. When oxidative stress (free radicals) are left unchecked, the ideal environment is created to allow DNA damage.

Proventigen SRM™ contains Longvida Optimized Curcumin developed by medical researchers. Proventigen’s Longvida Optimized® Curcumin is 65 times more bioavailable than generic Curcumin and this is achieved without the use of piperine, a potentially toxic agent that is found in many Curcumin formulations.

Estrogen Metabolism, COMT and Breast Health

Catecho-O-methyltransferase (COMT) is a key enzyme involved in estrogen metabolism. COMT is critical enzyme that helps metabolize estrogen into a less genotoxic form that can be DNA damaging. Folate and vitamin B12 help support COMT and estrogen metabolism.

Proventigen’s B-vitamin blend in Proventigen SRM™ was formulated by doctors using specific B-vitamins for estrogen metabolism. Proventigen’s B-complex contains: Folinic Acid (not synthetic folic acid), vitamin B12 (methylcobalamin) and vitamin B6 all in the most absorbable forms.

Pomegranates, Aromatase and Breast Health

Researchers have been studying the effects of pomegranates polyphenols and how they may act as a natural aromatase inhibitor. Aromatase is an enzyme that converts testosterone to estrogen. Inhibition of aromatase is a common strategy used today to balance estrogen metabolism.

Ellagitannins in Pomegranates work by Suppressing Aromatase

Proventigen contains POMELLA®, a pomegranate extract that is highly researched and is a rich source of polyphenols. Proventigen’s doctor’s chose POMELLA® pomegranate extract due to the supporting science and superior absorption.

Pomegranates have also been shown to influence another important enzyme in estrogen metabolism: Quinone Reductase. Quinone reductase reduces the highly reactive forms of estrogen that cause DNA mutations known as DNA adducts. By increasing quinone reductase, estrogen is not as likely to cause DNA mutations.

Proventigen’s patented POMELLA® pomegranate extract ensures your body is getting the most researched and absorbable pomegranate extract available to balance estrogen metabolism.  Support your breast health with Proventigen SRM™ capsules and powder.

NAC, Antioxidants and Breast Health

Mammogram

N-acetylcysteine (NAC) supports two very important pathways when it comes to breast health and estrogen metabolism – CYP1B1 and glutathione.

The CYP1B1 pathway metabolizes estrogen into a highly reactive estrogen that reacts with DNA and can cause mutations. NAC reduces CYP1B1 and supports a less genotoxic estrogen pathway.

The second pathway NAC supports is glutathione. Glutathione is our bodies most abundant and powerful antioxidant and detoxifier.

NAC provides the building blocks to ensure you have enough glutathione in your body and can bind to estrogen and eliminate it. Proventigen SRM™ contains pharmaceutical grade NAC to support breast health and estrogen metabolism.

Get started today on Proventigen SRM™ capsules or Proventigen SRM™ powder and begin Promoting Your Pathways To Health™!

Ingredients

• 1 scoop Proventigen SRM™ powder
• 2 ice cubes
• 1/2 cup  frozen organic blueberries
• 1/2 large banana, peeled and broken into chunks
• 1 scoop of ProWhey protein powder (optional)
• 4 oz of yogurt vanilla flavored (optional)
• 1 teaspoon honey to taste (optional)

Preparation

• In a blender, combine Proventigen SRM™ powder with ice cubes, blueberries, banana,  protein powder (optional), and honey to taste
• Cover and blend on high speed for 45 seconds
• Pour into tall glasses and serve immediately….yummmm!

RazzleDazzle Smoothie

Ingredients

• 1/2 cup frozen organic raspberries
• 1 scoop Proventigen SRM powder
• 1/2 banana
• 1 scoop of  creamy vanilla Prowhey protein
• 3/4 cup of water, organic rice milk or organic soy milk

Preparation

• In a blender, combine Proventigen SRM™ powder with organic raspberries, banana,  protein powder or vanilla yogurt (optional), water, organic rice or soy milk
• Cover and blend on high speed for 45-60 seconds
• Pour into tall glasses
• Garnish with mint
• Hold on to your taste buds, this is delicious!

Add A Community Recipe

• Have an idea for a smoothie recipe?  Share one with our community.  Best recipes will be featured monthly.

Triple Antioxidant Formulation For Kids

Proventigen SRM™ is a unique blend of botanicals including Curcumin, Pomegrante Polyphenols, N-acetylcysteine and select B-Vitamins that can support key pathways involved in children’s health.

Proventigen’s Selective Response Modulators™ (SRM) is a rich source of antioxidants and brings potent and powerful antioxidants together into a special formulation.

Get started today on Proventigen SRM™ capsules or Proventigen SRM™ powder and begin Promoting Your Child’s Pathways To Health™!

Proventigen’s Curcumin 65 Times More Absorbable Than Regular Curcumin

Curcumin is the active ingredient in the spice turmeric and has a multitude of important health benefits.

Curcumin Can Bind Heavy Metals and Increase Glutathione

Proventigen’s Longvida® Optimized Curcumin was created by a team of elite neuroscientists at a leading Southern California School of Medicine. They knew of Curcumin’s amazing benefits for the health, but also knew of Curcumin’s very poor absorption in the human body. The elite team of medical neuroscientists spent two years perfecting the ability of Curcumin to be absorbed into the bloodstream and brain.

Proventigen’s Longvida® Optimized Curcumin is 65 times better absorbed than generic Curcumin and does not contain piperine. Piperine is a black pepper extract that can interfere with detoxification and cause GI upset.

Proventigen’s Longvida® Optimized Curcumin uses a patent-pending all natural process called Solid Lipid Curcumin Particle or SLCP™.  SLCP™ is the ideal absorption-promoting system, based on real, live research data that was repeated over and over using validated analytical methodologies.

Curcumin Facts:

• Curcumin has potent anti-fungal actions.In a 2008 study, published in Journal of Antimicrobial Chemotherapy (vol. 63 number 2, pg-337-339), researchers reported that Curcumin was twice as potent as the common anti-fungal fluconazole in inhibiting Candida adhering to mucosa
• Curcumin binds heavy metals – numerous studies have demonstrated Curcumin’s ability to bind lead, cadmium, iron, copper and other metals
• Curcumin increases glutathione levels. Researchers have demonstrated that Curcumin increases glutathione levels in vitro and in vivo
• Curcumin has been show to lower TNF-alpha levels

Best of all, all ingredients in Proventigen’s Longvida® Optimized Curcumin are generally recognized as safe (GRAS) and free of harsh solvents, heavy metals or volatile oils. That makes the Curcumin in Proventigen SRM™ and ideal supplement to support the needs of special children.

Proventigen’s Triple Antioxidant Support

Proventigen SRM contains potent antioxidants

Proventigen’s Selective Response Modulators™ (SRM) is a rich source of antioxidants and brings three potent and powerful antioxidants together to support reduction of oxidative stress.

Proventigen’s Unique and Synergistic Antioxidant Blend – Curcumin, NAC and Pomegranate

• Curcumin: Patent-pending Longvida® Optimized Curcumin is a powerful antioxidant that has 65 times the absorption of regular Curcumin. Additionally, Proventigen’s Longvida® Optimized Curcumin has also been shown to cross the blood brain barrier adding additional neurological support
• NAC: Proventigen SRM™ includes N-acetylcysteine (NAC), a potent antioxidant.  NAC supports glutathione production and detoxification. Glutathione is the body’s most abundant anti-oxidant. Proventigen SRM™ uses pharmaceutical grade NAC in both its capsules and powder formulas
• Pomegranate: Proventigen’s SRM™ uses POMELLA®, a patented pomegranate extract and a highly powerful antioxidant. POMELLA® has been shown to decrease lipidoxidation by 32% in just 30 minutes after ingestion

Proventigen’s Blend of B-Vitamins

Dr. Jill James has conducted research and found that many children need to support methionine and homocysteine metabolism. Dr. James has advocated using folinic acid (not synthetic folic acid), vitamin B12 (as methylcobalamin) and vitamin B6 (pyridoxine) as supportive nutrients to support key pathways.

Proventigen’s SRM™ formula is designed with a B-complex blend combining three specific B-vitamins to help support methionine and homocysteine metabolism – Folinic acid, B12 and B6.

Try Proventigen SRM™ capsules or Proventigen SRM™ powder today !

Proventigen Supports Key Pathways for Prostate Health

Proventigen SRM supports prostate health. Proventigen SRM formulation contains key botanicals, pharmaceutical grade NAC and B-complex vitamins that target key pathways involved in prostate health.

Similar to breast health prostate health is also dependant on proper estrogen metabolism.

Proventigen SRM exclusive formula supports estrogen metabolism, reduced cytokine production and proper redox.

Key pathways involved in Prostate Health are:

• Aromatase
• Quinone Reductase
• Glutathione
• CYP1B1
• Catecho-O-methyltransferase (COMT)

Exposure to unbalanced estrogen metabolism is a known risk factor for developing a unhealthy prostate.  

Proventigen’s Selective Response Modulators SRM™ formula supports proper estrogen metabolism by addressing the key pathways involved in prostate health. Letting Nature Nurture.

Curcumin, CYP1B1 and Prostate Health

Curcumin reduces CYP1B1

Curcumin supports prostate health by reducing the biotransforming enzyme CYP1B1.

CYP1B1 is responsible for making the highly reactive estrogen intermediate that can mutate prostate DNA. Supporting CYP1B1 reduces the DNA adduct formations associated with unbalanced estrogen metabolism.

Curcumin is also a potent antioxidant. Elevated oxidative stress has been an underlying theme for many chronic condition. When oxidative stress (free radicals) are left unchecked it creates the perfect environment to allow DNA to become mutated. Patent-pending Longvida® Optimized Curcumin is 65 times more bioavailable than regular Curcumin — all without the use of piperine.

B-Vitamins, COMT and Prostate Health

Catecho-O-methyltransferase (COMT) is a key enzyme involved in estrogen metabolism. COMT is critical enzyme that helps metabolize estrogen into a less genotoxic form that can be DNA damaging. Folate and vitamin B12 help support COMT and estrogen metabolism.

Proventigen SRM™ includes B-vitamin blend formulated by doctors using specific B-vitamins for estrogen metabolism. Proventigen’s B-complex contains: Folinic Acid (not synthetic folic acid), vitamin B12 (methylcobalamin) and vitamin B6 all in the most absorbable forms.

Pomegranates, Aromatase and Prostate Health

There is growing scientific evidence that pomegranates ellagitannins contain very powerful agents and may play a role in prostate cancer treatment and chemoprevention. Researchers studying the effects of pomegranates polyphenols are looking at how pomegranates and their bioactive metabolites may act as a natural aromatase inhibitor. Aromatase is an enzyme that converts testosterone to estrogen. Inhibition of aromatase is a common strategy used today to balance estrogen metabolism.

POMELLA® Pomegranate Extract Can Inhibit Aromatase and Increase Quinone Reductase. Proventigen SRM™ contains POMELLA®, a pomegranate extract that supports healthy estrogen metabolism.

Proventigen SRM™ contains POMELLA®, a rich source of polyphenols and the most researched and bioavailable pomegranate extract available. Proventigen’s doctor’s chose POMELLA® pomegranate extract due to the supporting science and superior absorption.

Pomegranates have also been shown to increase another important enzyme in estrogen metabolism: Quinone Reductase.  Quinone reductase reduces the highly reactive forms of estrogen that cause DNA mutations known as DNA adducts. By increasing quinone reductase, estrogen is not as likely to cause DNA mutations.

Research studies conducted at major medical universities  have also shown that daily pomegranate use can support prostate health.

Proventigen’s patented POMELLA® pomegranate extract ensures your body is getting the most researched and absorbable pomegranate extract available to balance estrogen metabolism. Support your prostate health with Proventigen SRM™ capsules or powder.

NAC, Glutathione and Prostate Health

N-acetylcysteine (NAC) supports two very important pathways when it comes to prostate health and estrogen metabolism – CYP1B1 and glutathione.

The CYP1B1 pathway metabolizes estrogen into a highly reactive estrogen that reacts with DNA and can cause mutations. NAC reduces CYP1B1 and supports a less genotoxic estrogen pathway.

The second pathway NAC supports is glutathione. Glutathione is our bodies most abundant and powerful antioxidant and detoxifier.

NAC provides the building blocks to ensure you have enough glutathione in your body and can can bind to estrogen and eliminate it. Proventigen SRM™ contains pharmaceutical grade NAC to support prostate health and estrogen metabolism.

Get started today on Proventigen SRM™ capsules or Proventigen SRM™ powder and begin Promoting Your Pathways To Health™!

Every 70 seconds someone is diagnosed with dementia

Many people are concerned about maintaining proper brain health. It is estimated that 1 in 4 people in the US are concerned about their neurological health. Proventigen SRM™ capsules or powder are scientifically formulated to support brain health and maintain healthy pathways.

Proventigen’s unique formulation offers a well rounded array of support for brain and nerves, addressing the key pathways involved in neurological health.

Proventigen SRM™ is recommended by doctors and was formulated by doctors.

Proventigen’s Curcumin Developed by Medical Researchers Studying Neurological Conditions

Proventigen SRM™ powder formula contains Curcumin developed by elite medical researchers

An elite group of medical researchers at a leading Southern California School of Medicine have been studying the effects of Curcumin on neurological conditions. Curcumin is a natural substance found in the Indian spice turmeric, which gives curry its rich golden color.

This elite neuroscience medical team was intrigued by Curcumin’s ability to effect key pathways involved in brain health but were faced with significant challenges. It turns out that Curcumin is very poorly absorbed by our bodies, even when given at extremely high dosages (12,000 mg).

Some scientists have tried to trick the body into absorbing Curcumin by using piperine from black pepper, which can irritate the GI track by allowing Curcumin to “leak” inside the blood stream. Piperine has also been shown to interact with key drug metabolizing enzymes that can interfere with medications.

Proventigen's Longvida® Curcumin 65 times more absorbable than regular curcumin -- all without piperine

Researchers at a prestigious Southern California medical school took a completely new approach to achieving Curcumin absorption in the body. They knew if they could place Curcumin inside a natural lipid envelop our bodies could readily absorb it.  This task was much easier said then done. After hundreds of attempts and constant refinement and years in the making, UCLA’s team found success.

Not only were they able to make Curcumin 65 times more absorbable than generic Curcumin but they also were able to deliver it to their target – the BRAIN.

This landmark breakthrough with superior absorption has resulted in the patent-pending technology called SLCP™ and a compound known as Longvida® Optimized Curcumin. Proventigen has entered into a long term licensing agreement to use Longvida® Optimized Curcumin across Proventigen’s Selective Response Modulators™ (SRM) formula.

Proventigen’s doctors researched the power of Curcumin and reviewed hundreds of different studies before deciding on Longvida® Optimized Curcumin for Proventigen’s SRM™ formula.

Homocysteine Metabolism – Role of B Vitamins In Brain Health

B-Vitamins Support Healthy Homocysteine levels

Elevated homocysteine is considered a neurotoxic substance to the brain. Researchers have linked the elevation of homocysteine levels to a number of conditions. Maintaining healthy homocysteine pathways is important for brain health.

Our bodies use vitamin B12 and folic acid to support and balance homocysteine metabolism. Without sufficient B-vitamins, blood homocysteine levels can rise to harmful  levels.

Proventigen’s doctors chose the most bioavailable and absorbable forms of the key B-vitamins for Proventigen’s Selective Response Modulator™ (SRM) formula — Folate (folinic acid, not synthetic folic acid), vitamin B12, (Methylcobalamin) and vitamin B6 (pyridoxine) — to support healthy homocysteine metabolism.

Proventigen’s Antioxidant Rich Pomegranates Supports Brain Health

Proventigen's POMELLA® Extract contains Polyphenols, powerful Antioxidants

Greek philosophers called pomegranates the “Nectar of the Gods.” More recently medical researchers have looked at pomegranates effect on health and disease. Pomegranates are rich in plant chemicals known as polyphenols and unique to pomegranate is the polyphenols known as punicalagins.

Because punicalagins are known for their powerful antioxidant abilities, they have been studied for their effects in neurological health.

Proventigen’s doctors were impressed with the scientific support for pomegranates and set out to find the most research and bioavaialable pomegranate extract available. POMELLA® is a patented pomegranate extract with numerous scientific studies showing its superior absorption and antioxidant capacity. Each and every serving of Proventigen’s Selective Response Modulator™ (SRM) blend contains POMELLA® pomegranate extract.

Glutathione and Brain Health

N-acetylcysteine (NAC) is a powerful antioxidant and detoxifier and helps supports your body’s natural production of glutathione. Glutathione is a vital antioxidant and NAC provides the building blocks to ensure you have enough glutathione in your body and brain.

Researchers have looked at the role of glutathione in neurological conditions and found that glutathione is low. Antioxidants like NAC support glutathione production in our bodies. Supporting healthy glutathione levels seems to be an agreed upon strategy when it comes to brain health.

Proventigen’s doctors chose to use pharmaceutical grade NAC in Proventigen SRM™ to target and support healthy glutathione levels in the brain and body.

Get started today on Proventigen SRM™ capsules or Proventigen SRM™ powder and begin Promoting Your Pathways To Health™!  Stay focused and sharp with Proventigen SRM™.

Researchers in such diverse disciplines as cancer and Alzheimer’s disease have taken an interest to better understand and fund clinical trials on Curcumin effects.  While Curcumin has been call “a superstar” among botanicals, it has had one major draw back. That major draw back has to do with Curcumins poor absorption.  Scientists were able to demonstrate incredible health promoting properties of Curcumin in a test tube but when the gave it to living animals including humans they were disappointed with the results due to this poor absorption.

Recently an elite team of medical researchers studying Alzheimer’s disease at UCLA began trying to improve Curcumins absorption.  They spent nearly two years and hundreds of attempts in trying creating a more absorbable Curcumin.  The team of neuroscientist wanted to avoid using a common additive from black pepper called piperine as this can cause drug interactions.  After constant and steady refinement, the UCLA team achieved what they had set out to do.  Not only were they able to make Curcumin more absorbable but they were also able to deliver Curcumin to the target tissue….in there case this was the brain.  The result is Proventigens Longvida optimized Curcumin.  Proventigens Longvida optimized Curcumin is 65 times more absorbable than regular Curcumin, doesnt contain any piperine, volitle oils and is the subject of two current NIH Alzheimers studies!

Proventigens Longvida optimized Curcumin uses a patent pending process called Solid Lipid Curcumin Particle or SLCP.  This process uses all natural lipids to surround the Curcumin allowing for superior absorption……65 times better absorption!  Superior absorption with using any harsh solvents, chemicals or preservatives….all ingredients are GRAS…Generally Recognized As Safe.